| ncRNA name | Sox2ot |
| ncRNA Category | lncRNA |
| ID | 320478 |
| Ensembl | ENSMUSG00000105265 |
| Synonyms | B230215L15Rik |
| Disease name | diabetic retinopathy (DR) |
| Species | Mus musculus |
| Tissues/Cell_line | retinas |
| Methods | qRT-PCR, MTT assay, CCK-8 assay, Calcein-AM/PI staining, Hoechst staining, immunofluorescence, Western blot |
| Expression pattern | down-regulated |
| Functional description | SOX2OT knockdown protects RGCs against high glucose-induced injury in vitro and plays a neuroprotective role in diabetes-related retinal neurodegeneration in vivo. Sox2OT knockdown plays an anti-oxidative role via regulating NRF2/HO-1 signaling activity. |
| PubMed ID | 27193103 |
| Year | 2016 |
| Title | Long Noncoding RNA-Sox2OT Knockdown Alleviates Diabetes Mellitus-Induced Retinal Ganglion Cell (RGC) injury. |
| Drug-related ncRNA | NO |
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